Much ado has been made over the announcements about the longevity effects of dietary restrictions. But when I'm hungry I don't think that well and make mistakes, which theoretically reduces my life.
When cells are hungry they make mistakes as well. But some how those mistakes actually make cells live longer.
Hungry cells do a lot of things wrong, but perhaps their biggest mistakes is in producing one particular protein, production is an enzyme called TOR. Previous research has shown that less TOR means fewer proteins and longer cell life.
Scientists have made drugs that decrease TOR, but since TOR has many jobs the side effects of completely shutting down TOR are too severe.
Now University of Washington scientists have found a way to achieve the anti-aging effects of less TOR without the powerful side effects, at least in yeast cells.
The scientists decreased the amount of proteins inside a cell in two ways that both screwed up ribosomes, which help make proteins.
The scientists initially noticed that yeast cells with mutations in a specific part of ribosomes decreased protein production.
A drug, diazaborine, messes with the same part of the ribosome that the mutated yeast cells had, so the scientists treated the yeast cells with diazaborine and found that those cells lived 50% longer than normal and untreated cells.
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