Intelligence in a Pill

December 12, 2008

As a fan of vintage sci-fi, I’ve long been fascinated with Daniel Keyes’ 1966 novel Flowers for Algernon, the story of Charlie Gordon, a 37-year-old mentally disabled man whose IQ is boosted to 200-plus by an experimental operation, and the existential dilemma that results. The book was made into a movie, Charly, in 1968. Star Cliff Robertson won an Academy Award for best actor.

Four decades later, the book and film’s basic premise remains tantalizing. What if there were a way for us to suddenly become way, way smarter? I’m not just talking about  Are You Smarter Than a Fifth Grader? smarter, either. I’m talking scoring 165 or better on the Wechsler  or Stanford-Binet  scales, the generally accepted quantitative demarcation of genius.

But will artificially induced intellectual brilliance ever become possible? Hard to say. Scientists do know a bit more about the brain and how it works — and how that relates to intelligence -- than they did at the time that Flowers for Algernon was written, as this How Stuff Works article on the brain and genius details. A 2004 study at the University of California, Irvine, for example, found that sheer brain size is not as important as the volume of gray matter in parts of the cerebral cortex, while a 2006 National Institute of Mental Health study showed that the brain structures of very intelligent children develop differently than in kids of average intelligence. A 1999 analysis of the brain of proto-genius Albert Einstein suggests that physical attributes of many parts of the brain -- rather than a centralized "intelligence center" -- determine how smart a person is.

Einstein's brain was slightly smaller than the average brain. However, parts of his parietal lobe were wider than most people's brains. The larger areas in Einstein's brain are related to mathematics and spatial reasoning. Einstein's parietal lobe was also nearly missing a fissure found in most people's brains. Analysts theorized that the absence of the fissure meant that different regions of his brain could communicate better.

OK, so that all pretty much rules out the sort of surgical tweaking of intelligence that Keyes envisioned. (Oddly, though, Stanford University researchers have discovered that  gastric bypass surgery, for reasons that are not yet understood, seems to improve patients’ ability to remember, pay attention to detail and think through problems.)

Chemically enhancing intelligence may be a more promising route. Nootropics are a controversial class of drugs purported to boost brain performance by altering the availability of neurochemicals, increasing brain cell metabolism, improving oxygen supply to the brain, or stimulating the growth of new neurons. Already, an increasing number of people are experimenting with brain doping, using medications such as the attention-deficit drug Adderall and Provigil, a medication designed to treat narcolepsy, in an attempt to increase their powers of concentration and/or make cognitive breakthroughs. Twenty percent of the scientists who responded to a recent informal survey in the journal Nature admitted to using such drugs to enhance their brainpower. (From the Neuroanthropology blog, here’s a commentary on those findings.)  The real Viagra of brain doping, the pill capable of turning a pedestrian intellect into a truly high-powered one, has yet to be developed. But it strikes me that it may just be a matter of time.

So maybe this is the real question. Should scientists try to develop that sort of genius-in-a-capsule? You could argue that chemically enhanced super-intellects might find the cure for AIDS or develop a way to generate all the energy we need with a zero carbon footprint. But unless everyone had access to such a drug, next-generation brain dopers might form an oligarchy that would control a disproportionate share of wealth and power. And, as the sad examples of Sylvia Plath and David Foster Wallace illustrate, brilliance doesn’t translate automatically into happiness. Also, remember that things didn’t work out so well for Charlie Gordon, that fictional beneficiary of cognitive enhancement.

So, what do you think? Express your opinion below.


Patrick J. Kiger has written for print publications ranging from GQ to the Los Angeles Times Magazine, and is the co-author of two books, Poplorica: A popular history of the fads, mavericks, inventions and lore that shaped modern America," and Oops: 20 life lessons from the fiascoes that shaped America. For more of his work, check out his web site, www.patrickjkiger.com.
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